WHATEVER ails you, if you have to take two pills a day for it instead of one, you can blame metabolic clearance. Before they can get busy, drug molecules must run a biochemical gauntlet as the body's machinery tries to break them down. As a result, much of what is in a pill may be excreted in useless pieces before it has had a chance to work its wonders. Last month, though, America's pharmaceutical regulator, the Food and Drug Administration, received a request to approve a drug, currently calle...
WHATEVER ails you, if you have to take two pills a day for it instead of one, you can blame metabolic clearance. Before they can get busy, drug molecules must run a biochemical gauntlet as the body's machinery tries to break them down. As a result, much of what is in a pill may be excreted in useless pieces before it has had a chance to work its wonders. Last month, though, America's pharmaceutical regulator, the Food and Drug Administration, received a request to approve a drug, currently calle...
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